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H6pdtm1c(EUCOMM)Wtsi
Targeted Allele Detail
Summary
Symbol: H6pdtm1c(EUCOMM)Wtsi
Name: hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase); targeted mutation 1c, Wellcome Trust Sanger Institute
MGI ID: MGI:6449815
Synonyms: H6PDHfl
Gene: H6pd  Location: Chr4:150063932-150093480 bp, - strand  Genetic Position: Chr4, 80.65 cM
Alliance: H6pdtm1c(EUCOMM)Wtsi page
IMPC: H6pd gene page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:292236
Parent Cell Line:  JM8.N4 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsThe L1L2_st0 cassette was inserted at position 150078658 of Chromosome 4 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 150079496. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele. (J:292236)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any H6pd Mutation:  60 strains or lines available
References
Original:  J:292236 Wang J, et al., Lack of adipose-specific hexose-6-phosphate dehydrogenase causes inactivation of adipose glucocorticoids and improves metabolic phenotype in mice. Clin Sci (Lond). 2019 Nov 15;133(21):2189-2202
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory