H6pdtm1c(EUCOMM)Wtsi
Targeted Allele Detail
|
Symbol: |
H6pdtm1c(EUCOMM)Wtsi |
Name: |
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase); targeted mutation 1c, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:6449815 |
Synonyms: |
H6PDHfl |
Gene: |
H6pd Location: Chr4:150063932-150093480 bp, - strand Genetic Position: Chr4, 80.65 cM
|
Alliance: |
H6pdtm1c(EUCOMM)Wtsi page
|
IMPC: |
H6pd gene page |
|
Germline Transmission: |
Earliest citation of germline transmission:
J:292236
|
Parent Cell Line: |
JM8.N4 (ES Cell)
|
Strain of Origin: |
C57BL/6N
|
Project Collection: |
EUCOMM
|
|
Allele Type: |
|
Targeted (Conditional ready, No functional change) |
Mutation: |
|
Insertion
|
|
|
Mutation details: The L1L2_st0 cassette was inserted at position 150078658 of Chromosome 4 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 150079496. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele.
(J:292236)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any H6pd Mutation: |
60 strains or lines available
|
|
Original: |
J:292236 Wang J, et al., Lack of adipose-specific hexose-6-phosphate dehydrogenase causes inactivation of adipose glucocorticoids and improves metabolic phenotype in mice. Clin Sci (Lond). 2019 Nov 15;133(21):2189-2202 |
All: |
1 reference(s) |
|