Obsl1^tm1.1Slan
Targeted Allele Detail

Summary

• Symbol: Obsl1^tm1.1Slan
• Name: obscurin-like 1; targeted mutation 1.1, Stephan Lange
• MGI ID: MGI:6450042
• Gene: Obsl1 Location: Chr1:75462469-75483134 bp, - strand Genetic Position: Chr1, 39.15 cM
• Alliance: Obsl1^tm1.1Slan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:283623
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1, and a second loxP site followed by an FRT-flanked PGK-neo cassette was inserted downstream of exon 4. The neomycin selection cassette was removed via Flp-mediated recombination in the germline, leaving loxP sites flanking exon 4. (J:283623)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Obsl1 Mutation: 100 strains or lines available

References

• Original: J:283623 Blondelle J, et al., Murine obscurin and Obsl1 have functionally redundant roles in sarcolemmal integrity, sarcoplasmic reticulum organization, and muscle metabolism. Commun Biol. 2019;2:178
• All: 1 reference(s)