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Obsl1tm1.2Slan
Targeted Allele Detail
Summary
Symbol: Obsl1tm1.2Slan
Name: obscurin-like 1; targeted mutation 1.2, Stephan Lange
MGI ID: MGI:6450045
Synonyms: Obsl1 KO
Gene: Obsl1  Location: Chr1:75462469-75483134 bp, - strand  Genetic Position: Chr1, 39.15 cM
Alliance: Obsl1tm1.2Slan page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:283623
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 1, and a second loxP site followed by an FRT-flanked PGK-neo cassette was inserted downstream of exon 4. The neomycin selection cassette was removed via Flp-mediated recombination in the germline, and exon 4 was deleted via Cre-mediated recombination. (J:283623)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Obsl1 Mutation:  100 strains or lines available
References
Original:  J:283623 Blondelle J, et al., Murine obscurin and Obsl1 have functionally redundant roles in sarcolemmal integrity, sarcoplasmic reticulum organization, and muscle metabolism. Commun Biol. 2019;2:178
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory