Unc80^em2Dren
Endonuclease-mediated Allele Detail

Summary

• Symbol: Unc80^em2Dren
• Name: unc-80, NALCN activator; endonuclease-mediated mutation 2, Dejian Ren
• MGI ID: MGI:6451181
• Synonyms: L2654* KI
• Gene: Unc80 Location: Chr1:66507526-66738307 bp, + strand Genetic Position: Chr1, 33.56 cM
• Alliance: Unc80^em2Dren page

Mutation origin

• Strain of Origin: (C57BL/6J x SJL/J)F1

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 technology replaced the leucine-encoding codon CTA at position 2654 with a stop codon TAA (L2654*). (J:291847)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Unc80 Mutation: 184 strains or lines available

References

• Original: J:291847 Wie J, et al., Intellectual disability-associated UNC80 mutations reveal inter-subunit interaction and dendritic function of the NALCN channel complex. Nat Commun. 2020 Jul 3;11(1):3351
• All: 1 reference(s)