Ndrg1^{tm1(cre/ERT2)Myan}
Targeted Allele Detail

Summary

• Symbol: Ndrg1^{tm1(cre/ERT2)Myan}
• Name: N-myc downstream regulated gene 1; targeted mutation 1, Motoko Yanagita
• MGI ID: MGI:6451756
• Synonyms: Ndrg1^CreERT2
• Gene: Ndrg1 Location: Chr15:66801167-66841489 bp, - strand Genetic Position: Chr15, 29.3 cM, cytoband D3
• Alliance: Ndrg1^{tm1(cre/ERT2)Myan} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:261876
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Inducible, Null/knockout, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Ndrg1^{tm1(cre/ERT2)Myan} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Ndrg1 (MGI:1341799)

• Mutation details: The targeting vector was designed to insert Cre/ERT2 cassette, polyA tail, and loxP-flanked PGK-Neo cassette in the opposite transcriptional orientation to the first exon of the Ndrg1 gene at the position of the initiation codon. The knock-in allele disrupted the first exon, thereby deleting the expression of Ndrg1. (J:261876)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ndrg1 (mouse) Summary of all recombinase alleles driven by Ndrg1. Comparative matrix view of recombinase activities Alliance mouse Ndrg1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ndrg1 Mutation: 29 strains or lines available

References

• Original: J:261876 Endo T, et al., Exploring the origin and limitations of kidney regeneration. J Pathol. 2015 Jun;236(2):251-63
• All: 11 reference(s)