Pld4tm1.2Nemz
Targeted Allele Detail
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Symbol: |
Pld4tm1.2Nemz |
Name: |
phospholipase D family member 4; targeted mutation 1.2, David Nemazeez |
MGI ID: |
MGI:6451773 |
Synonyms: |
Pld4- |
Gene: |
Pld4 Location: Chr12:112727089-112735420 bp, + strand Genetic Position: Chr12, 61.2 cM
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Alliance: |
Pld4tm1.2Nemz page
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Germline Transmission: |
Earliest citation of germline transmission:
J:281205
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A loxP site and an FRT site flanked neomycin resistance gene cassette were inserted into intron 3 and a second loxP site into intron 6. The neo cassette was removed through subsequent flp-mediated recombination and exons 4-6 were deleted through cre-mediated recombination. Immunohistochemistry showed no peptide is expressed from this allele.
(J:281205)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Pld4 Mutation: |
26 strains or lines available
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Original: |
J:281205 Gavin AL, et al., PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing. Nat Immunol. 2018 Sep;19(9):942-953 |
All: |
3 reference(s) |
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