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Pld4tm1.2Nemz
Targeted Allele Detail
Summary
Symbol: Pld4tm1.2Nemz
Name: phospholipase D family member 4; targeted mutation 1.2, David Nemazeez
MGI ID: MGI:6451773
Synonyms: Pld4-
Gene: Pld4  Location: Chr12:112727089-112735420 bp, + strand  Genetic Position: Chr12, 61.2 cM
Alliance: Pld4tm1.2Nemz page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:281205
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site and an FRT site flanked neomycin resistance gene cassette were inserted into intron 3 and a second loxP site into intron 6. The neo cassette was removed through subsequent flp-mediated recombination and exons 4-6 were deleted through cre-mediated recombination. Immunohistochemistry showed no peptide is expressed from this allele. (J:281205)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pld4 Mutation:  26 strains or lines available
References
Original:  J:281205 Gavin AL, et al., PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing. Nat Immunol. 2018 Sep;19(9):942-953
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory