Pld3^em1Nemz
Endonuclease-mediated Allele Detail

Summary

• Symbol: Pld3^em1Nemz
• Name: phospholipase D family member 3; endonuclease-mediated mutation 1, David Nemazeez
• MGI ID: MGI:6451776
• Synonyms: Pld3^-
• Gene: Pld3 Location: Chr7:27231425-27252643 bp, - strand Genetic Position: Chr7, 15.92 cM
• Alliance: Pld3^em1Nemz page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 9 was targeted with a gRNA (5'-GGACTGGCGGTCGCTGACCC-3') using CRISPR/Cas9 technology. This allele represents founder line 7 which has a 1 bp insertion in exon 9: ATGGACTGGCGGTCGCTGAaCCCAG (insertion in lower case). (J:281205)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pld3 Mutation: 81 strains or lines available

References

• Original: J:281205 Gavin AL, et al., PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing. Nat Immunol. 2018 Sep;19(9):942-953
• All: 2 reference(s)