Gprc5a^em1Jaap
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gprc5a^em1Jaap
• Name: G protein-coupled receptor, family C, group 5, member A; endonuclease-mediated mutation 1, Jaakko Patrakka
• MGI ID: MGI:6452643
• Synonyms: Gprc5a^-
• Gene: Gprc5a Location: Chr6:135042660-135061707 bp, + strand Genetic Position: Chr6, 65.83 cM
• Alliance: Gprc5a^em1Jaap page

Mutation origin

• Strain of Origin: FVB

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A 2bp deletion (GT) was created close to the translation start site in exon 2 using TALENs. The resulting frameshift causes premature termination. Western blot and RT-PCR experiments confirmed the absence of expression from this allele. (J:293292)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gprc5a Mutation: 48 strains or lines available

References

• Original: J:293292 Ma X, et al., Depletion of Gprc5a Promotes Development of Diabetic Nephropathy. J Am Soc Nephrol. 2018 Jun;29(6):1679-1689
• All: 1 reference(s)