Zfyve1^em1Hbsh
Endonuclease-mediated Allele Detail

Summary

• Symbol: Zfyve1^em1Hbsh
• Name: zinc finger, FYVE domain containing 1; endonuclease-mediated mutation 1, H-B Shu
• MGI ID: MGI:6452968
• Gene: Zfyve1 Location: Chr12:83593332-83643996 bp, - strand Genetic Position: Chr12, 38.76 cM
• Alliance: Zfyve1^em1Hbsh page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting of exon 3 deleted the exon to produce a null allele. (J:292942)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zfyve1 Mutation: 165 strains or lines available

References

• Original: J:292942 Zhong X, et al., ZFYVE1 negatively regulates MDA5- but not RIG-I-mediated innate antiviral response. PLoS Pathog. 2020 Apr;16(4):e1008457
• All: 2 reference(s)