Fam170a^em1Osb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fam170a^em1Osb
• Name: family with sequence similarity 170, member A; endonuclease-mediated mutation 1, Osaka University
• MGI ID: MGI:6453859
• Gene: Fam170a Location: Chr18:50411436-50416087 bp, + strand Genetic Position: Chr18, 27.3 cM
• Alliance: Fam170a^em1Osb page

Mutation origin

• Strain of Origin: (C57BL/6NJcl x DBA/2NJcl)F2

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting produced a 2 bp deletion. qRT-PCR confirmed the absence of transcript expression in testis. (J:293721)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Fam170a Mutation: 26 strains or lines available

References

• Original: J:293721 Devlin DJ, et al., Knockout of family with sequence similarity 170 member A (Fam170a) causes male subfertility, while Fam170b is dispensable in mice. Biol Reprod. 2020 Aug 4;103(2):205-222
• All: 1 reference(s)