Fam170b^em2Osb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fam170b^em2Osb
• Name: family with sequence similarity 170, member B; endonuclease-mediated mutation 2, Osaka University
• MGI ID: MGI:6453868
• Gene: Fam170b Location: Chr14:32555938-32558746 bp, + strand Genetic Position: Chr14, 19.4 cM, cytoband A3
• Alliance: Fam170b^em2Osb page

Mutation origin

• Strain of Origin: (C57BL/6NJcl x DBA/2NJcl)F2

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting deleted 35 bp. Antibody staining confirmed the loss of protein expression in testis. (J:293721)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Fam170b Mutation: 21 strains or lines available

References

• Original: J:293721 Devlin DJ, et al., Knockout of family with sequence similarity 170 member A (Fam170a) causes male subfertility, while Fam170b is dispensable in mice. Biol Reprod. 2020 Aug 4;103(2):205-222
• All: 1 reference(s)