Ctrl^em1Toth
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ctrl^em1Toth
• Name: chymotrypsin-like; endonuclease-mediated mutation 1, Miklos Toth
• MGI ID: MGI:6454999
• Synonyms: Ctrl^{c.159_201del43}, Ctrl^p.D53EfsX52
• Gene: Ctrl Location: Chr8:106658635-106660494 bp, - strand Genetic Position: Chr8, 53.06 cM
• Alliance: Ctrl^em1Toth page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting of exon 3 deleted 43 bp resulting in a frame shift and premature termination. Western blot analysis confirmed the absence of pritein expression in the pancreas. (J:294035)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ctrl Mutation: 5 strains or lines available

References

• Original: J:294035 Mosztbacher D, et al., Loss of chymotrypsin-like protease (CTRL) alters intrapancreatic protease activation but not pancreatitis severity in mice. Sci Rep. 2020 Jul 16;10(1):11731
• All: 1 reference(s)