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Tmprss12em4Osb
Endonuclease-mediated Allele Detail
Summary
Symbol: Tmprss12em4Osb
Name: transmembrane (C-terminal) protease, serine 12; endonuclease-mediated mutation 4, Research Institute for Microbial Diseases, Osaka University
MGI ID: MGI:6455010
Synonyms: Tmprss12-8,-7871+5, Tmprss12del
Gene: Tmprss12  Location: Chr15:100178743-100190943 bp, + strand  Genetic Position: Chr15, 56.24 cM
Alliance: Tmprss12em4Osb page
Mutation
origin
Strain of Origin:  (C57BL/6J x DBA/2J)F2
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsCRISPR-targeting of exon 2 deleted 8 bp within the intron with the indel -7871 bp, +5 bp between intron 2 and exon 5 to produce a frameshift mutation with a premature stop codon at the 70th amino acid. Western blot analysis confirmed the absence of protein expression in testicular giant cells and spermatozoa. (J:293874)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Tmprss12 Mutation:  30 strains or lines available
References
Original:  J:293874 Larasati T, et al., Tmprss12 is required for sperm motility and uterotubal junction migration in mice. Biol Reprod. 2020 Aug 4;103(2):254-263
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory