Per2^tm3Jt
Targeted Allele Detail

Summary

• Symbol: Per2^tm3Jt
• Name: period circadian clock 2; targeted mutation 3, Joseph S Takahashi
• MGI ID: MGI:6455137
• Synonyms: Color-Switch PER2::iLuc
• Gene: Per2 Location: Chr1:91343699-91387028 bp, - strand Genetic Position: Chr1, 46.13 cM, cytoband C5
• Alliance: Per2^tm3Jt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:294210
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, Reporter)
• Mutation: Insertion
• Mutation details: A loxP-CBR (click beetle red luciferase) cDNA-neomycin (reversed)-Stop-loxP-CBG99 (click beetle green luciferase) cDNA cassette was introduced to the 3' end of the full length mouse Per2 open reading frame (ORF) in exon 23. The ATG start codons were omitted from the CBR and CBG components to minimize non-specific expression. (J:294210)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Per2 Mutation: 74 strains or lines available

References

• Original: J:294210 Shan Y, et al., Dual-Color Single-Cell Imaging of the Suprachiasmatic Nucleus Reveals a Circadian Role in Network Synchrony. Neuron. 2020 Aug 4
• All: 1 reference(s)