Cntd1^em2Atot
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cntd1^em2Atot
• Name: cyclin N-terminal domain containing 1; endonuclease-mediated mutation 2, Attila Toth
• MGI ID: MGI:6455147
• Synonyms: Cntd1^Q
• Gene: Cntd1 Location: Chr11:101170029-101179527 bp, + strand Genetic Position: Chr11, 64.56 cM
• Alliance: Cntd1^em2Atot page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: CRISPR-targeting of exon 1 introduced an indel that produced a mis-splicing mutation. The protein lacks 4 amino acids from the first alpha helix. (J:292293)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cntd1 Mutation: 13 strains or lines available

References

• Original: J:292293 Bondarieva A, et al., Proline-rich protein PRR19 functions with cyclin-like CNTD1 to promote meiotic crossing over in mouse. Nat Commun. 2020 Jun 18;11(1):3101
• All: 1 reference(s)