Kansl2tm1c(EUCOMM)Wtsi
Targeted Allele Detail
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Symbol: |
Kansl2tm1c(EUCOMM)Wtsi |
Name: |
KAT8 regulatory NSL complex subunit 2; targeted mutation 1c, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:6455411 |
Synonyms: |
Kansl2fl |
Gene: |
Kansl2 Location: Chr15:98415539-98432145 bp, - strand Genetic Position: Chr15, 54.52 cM, cytoband F2
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Alliance: |
Kansl2tm1c(EUCOMM)Wtsi page
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IMPC: |
Kansl2 gene page |
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Mutant Cell Line: |
EPD0240_1_A05 |
Germline Transmission: |
Earliest citation of germline transmission:
J:291094
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Parent Cell Line: |
JM8.N4 (ES Cell)
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Strain of Origin: |
C57BL/6N
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Project Collection: |
EUCOMM
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
Vector: L1L2_Bact_P
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Mutation details: The L1L2_Bact_P cassette was inserted at position 98426448 of Chromosome 15 upstream of the critical exon 5 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon 6 at position 98427781. The critical exons 5 and 6 are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml
(J:291094)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Kansl2 Mutation: |
40 strains or lines available
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Original: |
J:291094 Sheikh BN, et al., Neural metabolic imbalance induced by MOF dysfunction triggers pericyte activation and breakdown of vasculature. Nat Cell Biol. 2020 Jul;22(7):828-841 |
All: |
1 reference(s) |
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