Kat8^tm1.2Avo
Targeted Allele Detail

Summary

• Symbol: Kat8^tm1.2Avo
• Name: K(lysine) acetyltransferase 8; targeted mutation 1.2, Anne K Voss
• MGI ID: MGI:6455412
• Synonyms: Mof^fl
• Gene: Kat8 Location: Chr7:127511689-127525010 bp, + strand Genetic Position: Chr7, 69.83 cM
• Alliance: Kat8^tm1.2Avo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:291094
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted downstream of exon 1 and an frt-flanked neo cassette with a 3' loxP site was inserted upstream of exon 6. Cre-mediated recombination removed the selection cassette and left exons 2 through 5 floxed. (J:291094)

Expression

In Mice Carrying this Mutation:	47 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kat8 Mutation: 38 strains or lines available

References

• Original: J:291094 Sheikh BN, et al., Neural metabolic imbalance induced by MOF dysfunction triggers pericyte activation and breakdown of vasculature. Nat Cell Biol. 2020 Jul;22(7):828-841
• All: 1 reference(s)