Frem3^em1Osb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Frem3^em1Osb
• Name: Fras1 related extracellular matrix protein 3; endonuclease-mediated mutation 1, Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:6455416
• Gene: Frem3 Location: Chr8:81337709-81421985 bp, + strand Genetic Position: Chr8, 38.35 cM
• Alliance: Frem3^em1Osb page

Mutation origin

• Strain of Origin: (C57BL/6NJcl x DBA/2NJcl)F2

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting of exon 1 (20 bp downstream of the translation initiation site) deleted 5 bp and produce a null allele. (J:291067)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Frem3 Mutation: 103 strains or lines available

References

• Original: J:291067 Kiyozumi D, et al., Genetic mutation of Frem3 does not causeFraser syndrome in mice. Exp Anim. 2020 Jan 29;69(1):104-109
• All: 1 reference(s)