Cic^tm1.1Jip
Targeted Allele Detail

Summary

• Symbol: Cic^tm1.1Jip
• Name: capicua transcriptional repressor; targeted mutation 1.1, Jihye Paik
• MGI ID: MGI:6455747
• Synonyms: Cic^fl
• Gene: Cic Location: Chr7:24967129-24993584 bp, + strand Genetic Position: Chr7, 13.73 cM
• Alliance: Cic^tm1.1Jip page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:294338
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: KOMP targeting vector PG00139_Y_4_H08 was used to target the locus. This vector introduces an FRT site, LacZ cassette, loxP site, neomycin resistance gene cassette, a second FRT site and a second loxP site into intron 8, and a third loxP site into intron 11. The lacZ and neo cassettes were removed through subsequent flp-mediated recombination, leaving a conditional-ready allele with exons 9-11 floxed. (J:294338)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cic Mutation: 98 strains or lines available

References

• Original: J:294338 Hwang I, et al., CIC is a critical regulator of neuronal differentiation. JCI Insight. 2020 May 7;5(9)
• All: 1 reference(s)