Mcc^tm1.2Maija
Targeted Allele Detail

Summary

• Symbol: Mcc^tm1.2Maija
• Name: mutated in colorectal cancers; targeted mutation 1.2, Maija Kohonen-Corish
• MGI ID: MGI:6455801
• Synonyms: Mcc^delta
• Gene: Mcc Location: Chr18:44558127-44945249 bp, - strand Genetic Position: Chr18, 23.74 cM
• Alliance: Mcc^tm1.2Maija page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:294342
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 4 was replaced with the following sequences: a loxP site, a partial cDNA (from E330037C1Rik) containing exons 4-19, an FRT site flanked neomycin resistance gene cassette, a second loxP site, exon 4 splice acceptor site, the EGFP reporter gene, and a STOP cassette. The neo cassette was removed through subsequent flp-mediated recombination and the cDNA insert through cre-mediated recombination. This leaves a knockout reporter allele. (J:294342)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mcc Mutation: 59 strains or lines available

References

• Original: J:294342 Currey N, et al., Mouse Model of Mutated in Colorectal Cancer Gene Deletion Reveals Novel Pathways in Inflammation and Cancer. Cell Mol Gastroenterol Hepatol. 2019;7(4):819-839
• All: 1 reference(s)