Iah1^em1Kobam
Endonuclease-mediated Allele Detail

Summary

• Symbol: Iah1^em1Kobam
• Name: isoamyl acetate-hydrolyzing esterase 1 homolog; endonuclease-mediated mutation 1, Misato Kobayashi
• MGI ID: MGI:6456042
• Gene: Iah1 Location: Chr12:21366363-21373608 bp, + strand Genetic Position: Chr12, 8.3 cM
• Alliance: Iah1^em1Kobam page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting deleted 53 bp to create a frameshift and premature termination. Western blot analysis confirmed the absence of protein expression in several tissues. (J:289414)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Iah1 Mutation: 13 strains or lines available

References

• Original: J:289414 Masuya T, et al., Ablation of Iah1, a candidate gene for diet-induced fatty liver, does not affect liver lipid accumulation in mice. PLoS One. 2020;15(5):e0233087
• All: 1 reference(s)