Pdia6^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Pdia6^m1Btlr
• Name: protein disulfide isomerase associated 6; mutation 1, Bruce Beutler
• MGI ID: MGI:6456064
• Synonyms: baum
• Gene: Pdia6 Location: Chr12:17316590-17334786 bp, + strand Genetic Position: Chr12, 8.06 cM
• Alliance: Pdia6^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU) (Hypomorph)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a point mutation induced amino acid substitution of valine with alanine at position 32 (V32A). Western blot analysis confirmed reduced protein expression in several tissues. (J:288824)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdia6 Mutation: 30 strains or lines available

References

• Original: J:288824 Choi JH, et al., Essential cell-extrinsic requirement for PDIA6 in lymphoid and myeloid development. J Exp Med. 2020 Apr 6;217(4)
• All: 1 reference(s)