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Lrrc8eem1Bcgen
Endonuclease-mediated Allele Detail
Summary
Symbol: Lrrc8eem1Bcgen
Name: leucine rich repeat containing 8 family, member E; endonuclease-mediated mutation 1, Biocytogen LLC
MGI ID: MGI:6456566
Gene: Lrrc8e  Location: Chr8:4276827-4287470 bp, + strand  Genetic Position: Chr8, 1.99 cM, cytoband A1.1
Alliance: Lrrc8eem1Bcgen page
Mutation
origin
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Not Specified
    CRISPR-targeting generated a null allele. (J:288504)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lrrc8e Mutation:  38 strains or lines available
References
Original:  J:288504 Zhou C, et al., Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity. Immunity. 2020 May 19;52(5):767-781.e6
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory