Serinc5^em1Spst
Endonuclease-mediated Allele Detail

Summary

• Symbol: Serinc5^em1Spst
• Name: serine incorporator 5; endonuclease-mediated mutation 1, Spyridon Stavrou
• MGI ID: MGI:6456568
• Gene: Serinc5 Location: Chr13:92747646-92848455 bp, + strand Genetic Position: Chr13, 47.75 cM
• Alliance: Serinc5^em1Spst page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRIPSR/Cas9 technology generated an approximate 49 kb deletion comprising parts of exon 1 (including the initiation codon), exon 2, and the entire intron between these two exons. RT-qPCR showed that homozygotes exhibit significantly lower RNA transcript levels. (J:291232)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Serinc5 Mutation: 30 strains or lines available

References

• Original: J:291232 Timilsina U, et al., SERINC5 Potently Restricts Retrovirus Infection In Vivo. mBio. 2020 Jul 14;11(4)
• All: 1 reference(s)