About   Help   FAQ
Serinc3tm1b(KOMP)Wtsi
Targeted Allele Detail
Summary
Symbol: Serinc3tm1b(KOMP)Wtsi
Name: serine incorporator 3; targeted mutation 1b, Wellcome Trust Sanger Institute
MGI ID: MGI:6456580
Gene: Serinc3  Location: Chr2:163466577-163487767 bp, - strand  Genetic Position: Chr2, 84.38 cM
Alliance: Serinc3tm1b(KOMP)Wtsi page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:291232
Parent Cell Line:  JM8 (ES Cell)
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsCre-mediated excision of the parental Serinc5tm1a(KOMP)Wtsi allele resulted in the removal of the promoter-driven neomycin selection cassette and critical exon 3 leaving behind the inserted lacZ reporter sequence. RT-qPCR shows significantly lower mRNA transcript levels in homozygotes. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:291232)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Serinc3 Mutation:  44 strains or lines available
References
Original:  J:291232 Timilsina U, et al., SERINC5 Potently Restricts Retrovirus Infection In Vivo. mBio. 2020 Jul 14;11(4)
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/19/2024
MGI 6.24
The Jackson Laboratory