Serinc3tm1b(KOMP)Wtsi
Targeted Allele Detail
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Symbol: |
Serinc3tm1b(KOMP)Wtsi |
Name: |
serine incorporator 3; targeted mutation 1b, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:6456580 |
Gene: |
Serinc3 Location: Chr2:163466577-163487767 bp, - strand Genetic Position: Chr2, 84.38 cM
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Alliance: |
Serinc3tm1b(KOMP)Wtsi page
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Germline Transmission: |
Earliest citation of germline transmission:
J:291232
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Parent Cell Line: |
JM8 (ES Cell)
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Strain of Origin: |
C57BL/6N
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Cre-mediated excision of the parental Serinc5tm1a(KOMP)Wtsi allele resulted in
the removal of the promoter-driven neomycin selection cassette and critical exon 3 leaving behind the inserted lacZ reporter sequence. RT-qPCR shows significantly lower mRNA transcript levels in homozygotes. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml.
(J:291232)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Serinc3 Mutation: |
44 strains or lines available
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Original: |
J:291232 Timilsina U, et al., SERINC5 Potently Restricts Retrovirus Infection In Vivo. mBio. 2020 Jul 14;11(4) |
All: |
1 reference(s) |
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