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Serinc3tm1b(KOMP)Wtsi
Targeted Allele Detail
Summary
Symbol: Serinc3tm1b(KOMP)Wtsi
Name: serine incorporator 3; targeted mutation 1b, Wellcome Trust Sanger Institute
MGI ID: MGI:6456580
Gene: Serinc3  Location: Chr2:163466577-163487767 bp, - strand  Genetic Position: Chr2, 84.38 cM
Alliance: Serinc3tm1b(KOMP)Wtsi page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:291232
Parent Cell Line:  JM8 (ES Cell)
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsCre-mediated excision of the parental Serinc5tm1a(KOMP)Wtsi allele resulted in the removal of the promoter-driven neomycin selection cassette and critical exon 3 leaving behind the inserted lacZ reporter sequence. RT-qPCR shows significantly lower mRNA transcript levels in homozygotes. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:291232)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Serinc3 Mutation:  44 strains or lines available
References
Original:  J:291232 Timilsina U, et al., SERINC5 Potently Restricts Retrovirus Infection In Vivo. mBio. 2020 Jul 14;11(4)
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/05/2024
MGI 6.24
The Jackson Laboratory