Rbm7^em1Aki
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rbm7^em1Aki
• Name: RNA binding motif protein 7; endonuclease-mediated mutation 1, Shizuo Akira
• MGI ID: MGI:6456581
• Gene: Rbm7 Location: Chr9:48400001-48406599 bp, - strand Genetic Position: Chr9, 26.43 cM
• Alliance: Rbm7^em1Aki page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: CRISPR-targeting replaced exons 1 through 3 with a neomycin resistance cassette. Western blot analysis confirmed the absence of protein expression in the lungs. (J:288329)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rbm7 Mutation: 11 strains or lines available

References

• Original: J:288329 Fukushima K, et al., Dysregulated Expression of the Nuclear Exosome Targeting Complex Component Rbm7 in Nonhematopoietic Cells Licenses the Development of Fibrosis. Immunity. 2020 Mar 17;52(3):542-556.e13
• All: 1 reference(s)