Ralgapa1^tm1.1Schen
Targeted Allele Detail

Summary

• Symbol: Ralgapa1^tm1.1Schen
• Name: Ral GTPase activating protein, alpha subunit 1; targeted mutation 1.1, Shuai Chen
• MGI ID: MGI:6456667
• Synonyms: RalGAPalpha1^Thr735Ala
• Gene: Ralgapa1 Location: Chr12:55649681-55867952 bp, - strand Genetic Position: Chr12, 24.06 cM
• Alliance: Ralgapa1^tm1.1Schen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:287672
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Single point mutation
• Mutation details: A loxP site was inserted upstream of exon 15. An FRT-flanked neomycin resistance cassette was inserted downstream of the modified exon 16, containing the amino acid substitution of threonine with alanine at position 735 (T735A). Flp-mediated recombination removed the selection cassette. (J:287672)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ralgapa1 Mutation: 143 strains or lines available

References

• Original: J:287672 Chen Q, et al., Targeting RalGAPalpha1 in skeletal muscle to simultaneously improve postprandial glucose and lipid control. Sci Adv. 2019 Apr;5(4):eaav4116
• All: 1 reference(s)