Sugct^tm1.2Kald
Targeted Allele Detail

Summary

• Symbol: Sugct^tm1.2Kald
• Name: succinyl-CoA glutarate-CoA transferase; targeted mutation 1.2, Philipp Kaldis
• MGI ID: MGI:6456759
• Synonyms: Sugct^null
• Gene: Sugct Location: Chr13:17032057-17869380 bp, - strand Genetic Position: Chr13, 5.92 cM
• Alliance: Sugct^tm1.2Kald page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:293423
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was flanked by loxP sites and a FRT-flanked neomycin selection cassette was inserted. Flp-mediated recombination removed the neomycin cassette and cre-mediated recombination deleted exon 3 in the germline. (J:293423)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sugct Mutation: 33 strains or lines available

References

• Original: J:293423 Niska-Blakie J, et al., Knockout of the non-essential gene SUGCT creates diet-linked, age-related microbiome disbalance with a diabetes-like metabolic syndrome phenotype. Cell Mol Life Sci. 2020 Sep;77(17):3423-3439
• All: 1 reference(s)