Igs2^{em5(CAG-Mir802)Gpt}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Igs2^{em5(CAG-Mir802)Gpt}
• Name: intergenic site 2; endonuclease-mediated mutation 5, GemPharmatech Co., Ltd
• MGI ID: MGI:6456816
• Synonyms: H11-CAG-LSL-miR-802, mir-892^ki
• Gene: Igs2 Location: Chr11:3195460-3195497 bp Genetic Position: Chr11, Syntenic
• Alliance: Igs2^{em5(CAG-Mir802)Gpt} page

Mutation origin

• Strain of Origin: C57BL/6JGpt

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: CRISPR-targeting inserted a CAG promoter, floxed STOP cassette, Mir802 sequence and polyadenylation sequence was inserted into the docking site. (J:287584)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igs2 Mutation: 72 strains or lines available

References

• Original: J:287584 Zhang F, et al., Obesity-induced overexpression of miR-802 impairs insulin transcription and secretion. Nat Commun. 2020 Apr 14;11(1):1822
• All: 1 reference(s)