Chd3^tm1.1Cya
Targeted Allele Detail

Summary

• Symbol: Chd3^tm1.1Cya
• Name: chromodomain helicase DNA binding protein 3; targeted mutation 1.1, Cyagen Biosciences
• MGI ID: MGI:6456882
• Synonyms: Chd3-flox, Chd3^tm1.1Cgen
• Gene: Chd3 Location: Chr11:69234099-69260232 bp, - strand Genetic Position: Chr11, 42.53 cM
• Alliance: Chd3^tm1.1Cya page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:294633
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 12 and an FRT site flanked neomycin resistance gene cassette and a second loxP site into intron 20. The neo cassette was removed through subsequent flp-mediated recombination, leaving a conditional-ready allele with exons 13-20 floxed. (J:294633)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chd3 Mutation: 102 strains or lines available

References

• Original: J:294633 Xie J, et al., The chromatin-remodeling enzyme CHD3 plays a role in embryonic viability but is dispensable for early vascular development. PLoS One. 2020;15(7):e0235799
• All: 2 reference(s)