Smdt1^em2Fink
Endonuclease-mediated Allele Detail

Summary

• Symbol: Smdt1^em2Fink
• Name: single-pass membrane protein with aspartate rich tail 1; endonuclease-mediated mutation 2, Toren Finkel
• MGI ID: MGI:6457287
• Synonyms: EMERE^KO-2
• Gene: Smdt1 Location: Chr15:82229901-82233266 bp, + strand Genetic Position: Chr15, 38.56 cM, cytoband E2
• Alliance: Smdt1^em2Fink page

Mutation origin

• Strain of Origin: (C57BL/6J x CBA/J)F1/J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting of exon 1 deleted 118 bp. Western blot analysis confirmed the absence of protein expression in the heart, brain, and liver. (J:238984, J:287405)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smdt1 Mutation: 11 strains or lines available

References

• Original: J:238984 Liu JC, et al., MICU1 Serves as a Molecular Gatekeeper to Prevent In Vivo Mitochondrial Calcium Overload. Cell Rep. 2016 Aug 09;16(6):1561-73
• All: 2 reference(s)