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Tg(Thy1/THY1)mhT4Gsv
Transgene Detail
Summary
Symbol: Tg(Thy1/THY1)mhT4Gsv
Name: transgene insertion mhT4, Frank Grosveld
MGI ID: MGI:6458476
Synonyms: mhT4
Transgene: Tg(Thy1/THY1)mhT4Gsv  Location: unknown  
Alliance: Tg(Thy1/THY1)mhT4Gsv page
Transgene
origin
Strain of Origin:  (CBA x C57BL/10)F1
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Thy1/THY1)mhT4Gsv expresses 2 genes
 
Mutation detailsThis transgene consists of a hybrid Thy1 gene which contains 1.5 kb 5' flanking sequences of the murine Thy1 gene, a 5.7 kb EcoRI-ApaI mouse Thy1a (Thy1.1) gene fragment containing the first 4 exons (including exons 1a and 1b) and part of exon 4 that is fused to a 3.4 kb ApaI-EcoRI human THY1 DNA sequence containing the remaining noncoding part of exon IV plus 3' human flanking sequence. High levels of hybrid transgene expression is seen in glomerular podocytes. (J:133943)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:133943 Kollias G, et al., Ectopic expression of Thy-1 in the kidneys of transgenic mice induces functional and proliferative abnormalities. Cell. 1987 Oct 9;51(1):21-31
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory