Tg(Thy1/THY1)mhT4Gsv
Transgene Detail
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Symbol: |
Tg(Thy1/THY1)mhT4Gsv |
Name: |
transgene insertion mhT4, Frank Grosveld |
MGI ID: |
MGI:6458476 |
Synonyms: |
mhT4 |
Transgene: |
Tg(Thy1/THY1)mhT4Gsv Location: unknown
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Alliance: |
Tg(Thy1/THY1)mhT4Gsv page
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Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Thy1/THY1)mhT4Gsv expresses
2 genes
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
mouse |
Thy1 (MGI:98747) |
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hybrid of mouse and human sequences |
human |
THY1 (7070) |
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hybrid of mouse and human sequences |
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Mutation details: This transgene consists of a hybrid Thy1 gene which contains 1.5 kb 5' flanking sequences of the murine Thy1 gene, a 5.7 kb EcoRI-ApaI mouse Thy1a (Thy1.1) gene fragment containing the first 4 exons (including exons 1a and 1b) and part of exon 4 that is fused to a 3.4 kb ApaI-EcoRI human THY1 DNA sequence containing the remaining noncoding part of exon IV plus 3' human flanking sequence. High levels of hybrid transgene expression is seen in glomerular podocytes.
(J:133943)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:133943 Kollias G, et al., Ectopic expression of Thy-1 in the kidneys of transgenic mice induces functional and proliferative abnormalities. Cell. 1987 Oct 9;51(1):21-31 |
All: |
1 reference(s) |
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