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Tg(Thy1/THY1)hT13Gsv
Transgene Detail
Summary
Symbol: Tg(Thy1/THY1)hT13Gsv
Name: transgene insertion hT13, Frank Grosveld
MGI ID: MGI:6458479
Synonyms: hT13
Transgene: Tg(Thy1/THY1)hT13Gsv  Location: unknown  
Alliance: Tg(Thy1/THY1)hT13Gsv page
Transgene
origin
Strain of Origin:  (CBA x C57BL/10)F1
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Thy1/THY1)hT13Gsv expresses 2 genes
 
Mutation detailsThis transgene is a hybrid Thy1 gene in which a 0.8 kb BstEII-ApaI fragment containing part of exons 3 and 4 of the mouse gene was replaced with the homologous 0.96 kb BstEII-ApaI human THY1 gene fragment (containing the mature protein and transmembrane sequences) while the 5' and 3' flanking regions are mouse sequences. High expression of the hybrid transgene is seen in the kidney proximal tubular epithelium and in the brain. (J:133943)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:133943 Kollias G, et al., Ectopic expression of Thy-1 in the kidneys of transgenic mice induces functional and proliferative abnormalities. Cell. 1987 Oct 9;51(1):21-31
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory