Tg(Thy1/THY1)hT10Gsv
Transgene Detail

Summary

• Symbol: Tg(Thy1/THY1)hT10Gsv
• Name: transgene insertion hT10, Frank Grosveld
• MGI ID: MGI:6458481
• Synonyms: hT10
• Transgene: Tg(Thy1/THY1)hT10Gsv Location: unknown
• Alliance: Tg(Thy1/THY1)hT10Gsv page

Transgene origin

• Strain of Origin: (CBA x C57BL/10)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1/THY1)hT10Gsv expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  mouse

  Thy1 (MGI:98747)

  hybrid of mouse and human sequences

  human

  THY1 (7070)

  Thy1	(MGI:98747)

  hybrid of mouse and human sequences

• Mutation details: This transgene is a hybrid Thy1 gene in which a 0.8 kb BstEII-ApaI fragment containing part of exons 3 and 4 of the mouse gene was replaced with the homologous 0.96 kb BstEII-ApaI human THY1 gene fragment (containing the mature protein and transmembrane sequences) while the 5' and 3' flanking regions are mouse sequences. High expression of the hybrid transgene is seen in the kidney proximal tubular epithelium and in the brain. (J:133943)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:133943 Kollias G, et al., Ectopic expression of Thy-1 in the kidneys of transgenic mice induces functional and proliferative abnormalities. Cell. 1987 Oct 9;51(1):21-31
• All: 1 reference(s)