Echs1^em1Jynz
Endonuclease-mediated Allele Detail

Summary

• Symbol: Echs1^em1Jynz
• Name: enoyl Coenzyme A hydratase, short chain, 1, mitochondrial; endonuclease-mediated mutation 1, Jian-Yuan Zhao
• MGI ID: MGI:6458749
• Gene: Echs1 Location: Chr7:139685623-139696334 bp, - strand Genetic Position: Chr7, 85.12 cM
• Alliance: Echs1^em1Jynz page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting deleted 10 bp in exon 2. (J:283707)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Echs1 Mutation: 23 strains or lines available

References

• Original: J:283707 Qu YY, et al., Inactivation of the AMPK-GATA3-ECHS1 Pathway Induces Fatty Acid Synthesis That Promotes Clear Cell Renal Cell Carcinoma Growth. Cancer Res. 2020 Jan 15;80(2):319-333
• All: 1 reference(s)