Fmo3^em1Jmbn
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fmo3^em1Jmbn
• Name: flavin containing monooxygenase 3; endonuclease-mediated mutation 1, J Mark Brown
• MGI ID: MGI:6458889
• Gene: Fmo3 Location: Chr1:162781369-162812097 bp, - strand Genetic Position: Chr1, 70.34 cM
• Alliance: Fmo3^em1Jmbn page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting of exon 2 produced a 7 bp deletion with a premature termination at amino acid position 98. (J:254352, J:279143)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fmo3 Mutation: 40 strains or lines available

References

• Original: J:254352 Schugar RC, et al., The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue. Cell Rep. 2017 Jun 20;19(12):2451-2461
• All: 2 reference(s)