Cc2d1a^tm1.2Thkn
Targeted Allele Detail

Summary

• Symbol: Cc2d1a^tm1.2Thkn
• Name: coiled-coil and C2 domain containing 1A; targeted mutation 1.1, Thomas Klein
• MGI ID: MGI:6458917
• Gene: Cc2d1a Location: Chr8:84859457-84874546 bp, - strand Genetic Position: Chr8, 40.32 cM
• Alliance: Cc2d1a^tm1.2Thkn page
• IMPC: Cc2d1a gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:236761
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 13. An additional loxP site was inserted upstream of exon 7. Cre-mediated recombination removed the selection cassette and exons 7 through 13 floxed. (J:236761)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cc2d1a Mutation: 32 strains or lines available

References

• Original: J:236761 Drusenheimer N, et al., The Mammalian Orthologs of Drosophila Lgd, CC2D1A and CC2D1B, Function in the Endocytic Pathway, but Their Individual Loss of Function Does Not Affect Notch Signalling. PLoS Genet. 2015 Dec;11(12):e1005749
• All: 1 reference(s)