Cc2d1b^{tm1c(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Cc2d1b^{tm1c(KOMP)Wtsi}
• Name: coiled-coil and C2 domain containing 1B; targeted mutation 1c, Wellcome Trust Sanger Institute
• MGI ID: MGI:6459258
• Synonyms: Cc2d1b^flox
• Gene: Cc2d1b Location: Chr4:108477137-108491320 bp, + strand Genetic Position: Chr4, 50.64 cM
• Alliance: Cc2d1b^{tm1c(KOMP)Wtsi} page
• IMPC: Cc2d1b gene page

Mutation origin

• Mutant Cell Line: EPD0017_2_C11
• Germline Transmission: Earliest citation of germline transmission: J:236761
• Parent Cell Line: JM8 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion Vector: L1L2_st0
• Mutation details: The L1L2_st0 cassette was inserted at position 108480157 of Chromosome 4 upstream of the critical exon 3 (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon 3 at position 108481080. The critical exon 3 is thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:236761)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cc2d1b Mutation: 42 strains or lines available

References

• Original: J:236761 Drusenheimer N, et al., The Mammalian Orthologs of Drosophila Lgd, CC2D1A and CC2D1B, Function in the Endocytic Pathway, but Their Individual Loss of Function Does Not Affect Notch Signalling. PLoS Genet. 2015 Dec;11(12):e1005749
• All: 1 reference(s)