Ts(17¹⁶)66Yah
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ts(17¹⁶)66Yah
• Name: trisomy, Chr 16 translocation to Chr 17, Yann Herault 66
• MGI ID: MGI:6459295
• Synonyms: Ts66Yah
• Gene: Ts(17¹⁶)66Yah Location: unknown Genetic Position: Chr17, Syntenic

Mutation origin

• Strain of Origin: B6EiC3Sn a/A-Ts(17¹⁶)65Dn/J

Mutation description

• Allele Type: Endonuclease-mediated (Inserted expressed sequence)
• Mutations: Intragenic deletion, Translocation
• Mutation details: CRISPR targeting removed a 6 Mb segment from the centromeric region of the Mmu17 chromosome of the original translocation, encompassing many genes not homologous to Hsa21. (J:331897)

Disease models

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ts(17 16 )66Yah Mutation: 2 strains or lines available

References

• Original: J:331897 Duchon A, et al., Ts66Yah, a mouse model of Down syndrome with improved construct and face validity. Dis Model Mech. 2022 Dec 1;15(12):dmm049721
• All: 3 reference(s)