Ts(17¹⁶)66Yah
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ts(17¹⁶)66Yah
• Name: trisomy, Chr 16 translocation to Chr 17, Yann Herault 66
• MGI ID: MGI:6459295
• Synonyms: Ts66Yah
• Gene: Ts(17¹⁶)66Yah Location: unknown Genetic Position: Chr17, Syntenic

Mutation origin

• Strain of Origin: B6EiC3Sn a/A-Ts(17¹⁶)65Dn/J

Mutation description

• Allele Type: Endonuclease-mediated (Inserted expressed sequence)
• Mutations: Intragenic deletion, Translocation
• Mutation details: CRISPR targeting removed a 6 Mb segment from the centromeric region of the Mmu17 chromosome of the original translocation, encompassing many genes not homologous to Hsa21. (J:331897)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
Loading...
ot1  Disease Model	Ts(17^16)66Yah/0	involves: C3H/HeSnJ * C57BL/6JEiJ * DBA/2J

Phenotypes:

Affected Systems	ot1
show or hide all annotated terms
behavior/neurological	√
behavior/neurological phenotype	N
impaired spatial learning	√
abnormal response to novel object	√
abnormal nest building behavior	√
cellular	√
oligozoospermia	√
asthenozoospermia	√
nervous system	√
abnormal brain morphology	√
reproductive system	√
oligozoospermia	√
asthenozoospermia	√
reduced male fertility	√

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Key:

√

disease model

expected model not found

Models:

Human Diseases	ot1
Down syndrome IDs Down syndrome       DOID:14250 ICD10CM:Q90 ICD9CM:758.0 MESH:D004314 NCI:C2993 OMIM:190685 ORDO:870 UMLS_CUI:C0013080 Close	√

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ts(17 16 )66Yah Mutation: 2 strains or lines available

References

• Original: J:331897 Duchon A, et al., Ts66Yah, a mouse model of Down syndrome with improved construct and face validity. Dis Model Mech. 2022 Dec 1;15(12):dmm049721
• All: 3 reference(s)