Dcp2^tm1.1Smoc
Targeted Allele Detail

Summary

• Symbol: Dcp2^tm1.1Smoc
• Name: decapping mRNA 2; targeted mutation 1.1, Shanghai Model Organisms Center
• MGI ID: MGI:6459898
• Synonyms: Dcp2^delta
• Gene: Dcp2 Location: Chr18:44513569-44558036 bp, + strand Genetic Position: Chr18, 23.74 cM, cytoband B3
• Alliance: Dcp2^tm1.1Smoc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:292283
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 2. Cre-mediated recombination removed exon 2 and the selection cassette. Western blot analysis confirmed that only trace amounts of protein are expressed. (J:292283)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dcp2 Mutation: 39 strains or lines available

References

• Original: J:292283 Li RM, et al., Global deletion of the RNA decapping enzyme Dcp2 postnatally in male mice results in infertility. Biochem Biophys Res Commun. 2020 May 28;526(2):512-518
• All: 1 reference(s)