Tg(Myh6-ACE2)2Rbre
Transgene Detail

Summary

• Symbol: Tg(Myh6-ACE2)2Rbre
• Name: transgene insertion 2, Roger E Breitbart
• MGI ID: MGI:6459903
• Transgene: Tg(Myh6-ACE2)2Rbre Location: unknown
• Alliance: Tg(Myh6-ACE2)2Rbre page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-ACE2)2Rbre expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ACE2 (59272)

  Ace2	(MGI:1917258)

• Tg(Myh6-ACE2)2Rbre expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Myh6 (MGI:97255)

• Mutation details: The human ACE2 cDNA is under the control of the mouse cardiac alpha-myosin heavy chain promoter. Two lines (1 and 2) were generated. Line 2 is a high expression line. Western blot analysis confirmed expression in the heart but not in lung, liver, kidney, or spleen. However, analysis of hearts shows that protein is progressively downregulated with increasing age. (J:128793)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:128793 Donoghue M, et al., Heart block, ventricular tachycardia, and sudden death in ACE2 transgenic mice with downregulated connexins. J Mol Cell Cardiol. 2003 Sep;35(9):1043-53
• All: 2 reference(s)