Gt(ROSA)26Sor^{tm1(CARD14*)Ribt}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CARD14*)Ribt}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Rudi Beyaert
• MGI ID: MGI:6459917
• Synonyms: Rosa26^{LSL-CARD14-E138A}
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CARD14*)Ribt} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:292094
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Mutation details: The targeting vector inserted into the locus a floxed triple polyadenylation sequence, a human coding sequence with the amino acid substitution of glutamic acid for alanine at position 138 (E138AS), an IRES sequence, and an EGFP reporter gene. (J:292094)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:292094 Van Nuffel E, et al., MALT1 targeting suppresses CARD14-induced psoriatic dermatitis in mice. EMBO Rep. 2020 Jul 3;21(7):e49237
• All: 1 reference(s)