Ikzf4^tm1.1Etms
Targeted Allele Detail

Summary

• Symbol: Ikzf4^tm1.1Etms
• Name: IKAROS family zinc finger 4; targeted mutation 1.1, Ethan M Shevach
• MGI ID: MGI:6460134
• Synonyms: Eos^-
• Gene: Ikzf4 Location: Chr10:128466712-128505227 bp, - strand Genetic Position: Chr10, 77.11 cM, cytoband D3
• Alliance: Ikzf4^tm1.1Etms page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:295208
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The last three exons, 6-8, were replaced with the following: a loxP site flanked neomycin resistance gene cassette, exon 8 splice acceptor sequence, IRES sequence, and the lacZ reporter gene. This creates a reporter-knockout allele. The neo cassette was removed through cre-mediated recombination. Lack of mRNA and protein expression from this allele was confirmed. (J:295208)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ikzf4 Mutation: 33 strains or lines available

References

• Original: J:295208 Rieder SA, et al., Eos Is Redundant for Regulatory T Cell Function but Plays an Important Role in IL-2 and Th17 Production by CD4+ Conventional T Cells. J Immunol. 2015 Jul 15;195(2):553-63
• All: 2 reference(s)