Ros1^em1Osb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ros1^em1Osb
• Name: Ros1 proto-oncogene; endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:6460274
• Gene: Ros1 Location: Chr10:51921817-52071340 bp, - strand Genetic Position: Chr10, 26.18 cM
• Alliance: Ros1^em1Osb page

Mutation origin

• Strain of Origin: (C57BL/6NJcl x DBA/2NJcl)F2

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting of exon 18 through exon 35 deleted 52, 533 bp. (J:290452)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ros1 Mutation: 145 strains or lines available

References

• Original: J:290452 Kiyozumi D, et al., NELL2-mediated lumicrine signaling through OVCH2 is required for male fertility. Science. 2020 Jun 5;368(6495):1132-1135
• All: 3 reference(s)