Ovch2^em1Osb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ovch2^em1Osb
• Name: ovochymase 2; endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:6460276
• Gene: Ovch2 Location: Chr7:107380751-107400386 bp, - strand Genetic Position: Chr7, 57.21 cM
• Alliance: Ovch2^em1Osb page

Mutation origin

• Strain of Origin: (C57BL/6NJcl x DBA/2NJcl)F2

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting of exon 4 through exon 7 deleted the exons 5 and 6. (J:290452)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ovch2 Mutation: 46 strains or lines available

References

• Original: J:290452 Kiyozumi D, et al., NELL2-mediated lumicrine signaling through OVCH2 is required for male fertility. Science. 2020 Jun 5;368(6495):1132-1135
• All: 1 reference(s)