Adtrp^tm1.1Clu
Targeted Allele Detail

Summary

• Symbol: Adtrp^tm1.1Clu
• Name: androgen dependent TFPI regulating protein; targeted mutation1.1, Cristina Lupu
• MGI ID: MGI:6460464
• Synonyms: Adtrp^-, Adtrp^Flpe-Del
• Gene: Adtrp Location: Chr13:41916621-42001092 bp, - strand Genetic Position: Chr13, 20.61 cM
• Alliance: Adtrp^tm1.1Clu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:295059
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted into intron 1, a second loxP site and an FRT site flanked neomycin resistance gene cassette into intron 2, a third loxP site into intron 4, and a fourth loxP site and an FRT site flanked hygromycin resistance gene cassette into intron 5. Subsequent ROSA26-Flpe-mediated deletion of the neo and hygro cassettes also deleted exons 3-5 in some mice, creating this knockout allele. Very low expression levels from this allele were confirmed by qPCR. (J:295059)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adtrp Mutation: 22 strains or lines available

References

• Original: J:295059 Patel MM, et al., Role of ADTRP (Androgen-Dependent Tissue Factor Pathway Inhibitor Regulating Protein) in Vascular Development and Function. J Am Heart Assoc. 2018 Nov 20;7(22):e010690
• All: 1 reference(s)