4930451I11Rik^em1Osb
Endonuclease-mediated Allele Detail

Summary

• Symbol: 4930451I11Rik^em1Osb
• Name: RIKEN cDNA 4930451I11 gene; endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:6460465
• Gene: 4930451I11Rik Location: Chr7:126429640-126430712 bp, - strand Genetic Position: Chr7, 69.25 cM
• Alliance: 4930451I11Rik^em1Osb page

Mutation origin

• Strain of Origin: (C57BL/6NJcl x DBA/2NJcl)F2

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 mediated recombination created a 1 bp deletion in exon 2 resulting in a premature termination codon at the 43rd amino acid. This is predicted to disrupt both the transmembrane and secreted isoforms. (J:287619)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any 4930451I11Rik Mutation: 16 strains or lines available

References

• Original: J:287619 Fujihara Y, et al., Spermatozoa lacking Fertilization Influencing Membrane Protein (FIMP) fail to fuse with oocytes in mice. Proc Natl Acad Sci U S A. 2020 Apr 28;117(17):9393-9400
• All: 2 reference(s)