Impg2^em2Xjz
Endonuclease-mediated Allele Detail

Summary

• Symbol: Impg2^em2Xjz
• Name: interphotoreceptor matrix proteoglycan 2; endonuclease-mediated mutation 2, Xianjun Zhu
• MGI ID: MGI:6466713
• Synonyms: Impg2 Mut2
• Gene: Impg2 Location: Chr16:56024676-56094119 bp, + strand Genetic Position: Chr16, 33.91 cM
• Alliance: Impg2^em2Xjz page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 2 was targeted with sgRNAs using CRISPR/Cas9 technology, resulting in three discontinuous deletions (17 + 6 + 1 bp). (J:295355)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Impg2 Mutation: 69 strains or lines available

References

• Original: J:295355 Xu H, et al., Deletion of the Impg2 gene causes the degeneration of rod and cone cells in mice. Hum Mol Genet. 2020 Jun 27;29(10):1624-1634
• All: 1 reference(s)