Ikzf4^tm1Djr
Targeted Allele Detail

Summary

• Symbol: Ikzf4^tm1Djr
• Name: IKAROS family zinc finger 4; targeted mutation 1, Derrick Rossi
• MGI ID: MGI:6467011
• Synonyms: Eos^fl
• Gene: Ikzf4 Location: Chr10:128466712-128505227 bp, - strand Genetic Position: Chr10, 77.11 cM, cytoband D3
• Alliance: Ikzf4^tm1Djr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187667
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted upstream of exon 1 and into intron 4, creating a conditional-ready allele with exons 1-4 floxed. (J:187667)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ikzf4 Mutation: 33 strains or lines available

References

• Original: J:187667 Fu W, et al., A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells. Nat Immunol. 2012 Oct;13(10):972-80
• All: 2 reference(s)