Cd274^{em1(CD274)Smoc}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cd274^{em1(CD274)Smoc}
• Name: CD274 antigen; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
• MGI ID: MGI:6467249
• Synonyms: Cd274^{em1(hPD-L1)Smoc}, hPD-L1 KI
• Gene: Cd274 Location: Chr19:29344855-29365495 bp, + strand Genetic Position: Chr19, 23.88 cM, cytoband C2
• Alliance: Cd274^{em1(CD274)Smoc} page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Cd274^{em1(CD274)Smoc} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CD274 (29126)

  Cd274

  (MGI:1926446)

• The coding sequence in exon 2 was replaced with the human sequence using CRISPR-targeting. (J:288117)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd274 Mutation: 71 strains or lines available

References

• Original: J:288117 Zhang X, et al., Distinct contribution of PD-L1 suppression by spatial expression of PD-L1 on tumor and non-tumor cells. Cell Mol Immunol. 2019 Apr;16(4):392-400
• All: 1 reference(s)